In acute kidney injury, renal tubular cells are damaged and inflammatory cells are recruited to resolve the injury by helping to restore the local tissue environment. However, if inflammatory cells fail to resolve the injury, this leads to myofibroblast activation, deposition of collagen and build-up of fibrosis. In aged kidneys, the resolution of the inflammation is delayed. By contrast, paracrine factors released by mesenchymal stromal cells acting as regenerative medicine therapies can modulate the inflammatory response and lead to resolution by promoting anti-inflammatory immune cells. How this endogenous regenerative process is regulated across different age groups, and how the inflammatory response can be modulated either in ageing, or through therapeutic intervention, is not well understood. Specifically, the interplay between inflammatory cells, damaged kidney cells and cytokines needs further detailed analysis, which can serve as an exemplar for processes of tissue inflammation and resolution in other organs systems.

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Studentships are funded by the Biotechnology and Biological Sciences Research Council (BBSRC) for 4 years. Funding will cover tuition fees at the UK rate only, a Research Training and Support Grant (RTSG) and stipend. We aim to support the most outstanding applicants from outside the UK and are able to offer a limited number of bursaries that will enable full studentships to be awarded to international applicants. These full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme.

Open to students worldwide

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