PhD

Molecular and Integrative Physiology

Study mode:On campus Study type:Full-time Languages: English
Foreign:$ 83 k / Year(s) Deadline: Dec 1, 2025
22 place StudyQA ranking:7665 Duration:

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The Molecular and Integrative Physiology program at the University of Michigan - Ann Arbor offers students an in-depth exploration of the complex biological mechanisms that underlie bodily functions and health. This interdisciplinary program is designed to provide a comprehensive understanding of the molecular basis of physiological processes, integrating knowledge from biochemistry, cell biology, genetics, and systems physiology. Students in this program will study how molecules and cells work together to maintain homeostasis, respond to environmental changes, and contribute to disease states. The curriculum includes a combination of rigorous coursework, laboratory training, and research opportunities that enable students to develop a strong foundation in scientific principles and experimental techniques. Emphasis is placed on the integration of molecular insights with organismal physiology, preparing graduates for careers in biomedical research, healthcare, or further academic study. The program aims to equip students with critical thinking skills, experimental competence, and a broad perspective on human health and disease. Students have access to state-of-the-art laboratories and work alongside leading researchers in the field of physiology and molecular biology. The degree prepares students for advanced graduate studies, professional schools, or industry roles where understanding the molecular basis of physiological processes is essential. Through a combination of coursework, hands-on research, and collaboration, students will gain valuable experience in designing experiments, analyzing data, and communicating scientific findings. The university's vibrant academic community supports students in their pursuit of scientific excellence and innovation. Ultimately, the Molecular and Integrative Physiology program at the University of Michigan offers a rigorous and engaging educational experience that melds fundamental science with applied health sciences, fostering the development of future leaders in biomedical research and healthcare.

Physiology (Subject Code: PHYSIOL)

404.  Hum Physiol Lab.  Required pre-requisite: [PHYSIOL 201 or 502; (C- or better)] or Graduate Standing  (2 credits)

405.  Research Problems.  (1 to 4 credits)

415.  Methods in Biology.  (1 to 2 credits)

500.  Physiol Med Student.  Advisory pre-requisite: Medical student or graduate standing.  (4 credits)

502.  Human Physiology.  Advisory pre-requisite: Introduction to biology and biochemistry.  (4 credits)

503.  Use&Care Lab Animal.  Advisory pre-requisite: Permission of instructor.  (1 credits)

505.  Physiol Lab.  Required pre-requisite: PHYSIOL 404; or Graduate Standing  Advisory pre-requisite: PHYS G STU  (2 credits)

506.  Extreme Physiology.  Required pre-requisite: (PHYSIOL 201 or 301 or BIOLOGY 225); and Graduate Standing  (3 credits)

510.  Systems&Integrative.  Advisory pre-requisite: Inorganic and organic chemistry; undergraduate course work in biology.  (4 credits)

511.  Systems&Integrative.  Advisory pre-requisite: Inorganic and organic chemistry; undergraduate coursework in biology  (3 credits)

519/BIOMEDE 519.  Quantitative Physiol.  Advisory pre-requisite: BIOLCHEM 310  (4 credits)

520/BIOINF 520.  Computat Systems Bio.  Advisory pre-requisite: An introductory course in calculus is desired but not essential and one year of biology.  (3 credits)

540.  Cell&Molecular Phys.  Advisory pre-requisite: Biol. 105 or equivalent; Chem. 468 or equivalent; and Biol. Chem. 515 or equivalent; permission of instructor.  (4 credits)

541/ANATOMY 541/PSYCH 532.  Mammal Reprod Physio.  Required pre-requisite: MCDB 310 or BIOLCHEM 415 or CHEM 351; (C or better)  Advisory pre-requisite: PHYSIOL 201 or PHYSIOL 502 or BIOL 225  (4 credits)

545/KINESLGY 545.  Metab Respon to Exer.  Advisory pre-requisite: MOVESCI 340 or equivalent and graduate student standing, or permissions of the instructor  (3 credits)

555.  Method and Logic.  (3 credits)

576.  Signal Transduction.  Advisory pre-requisite: Two terms of organic chemistry; BIOLCHEM 415 or 451/452. Physical Chemistry is strongly recommended.  (1 credits)

577.  Membrane&Cell Phys.  (2 credits)

590/BIOLCHEM 590/PHRMACOL 590.  Mole&Cell Endoc.  Advisory pre-requisite: Permission of instructor.  (2 credits)

591/BIOLCHEM 591/PHRMACOL 591.  Signal Transduction.  Advisory pre-requisite: Course in Biochemistry and signal transduction or Instructor permission  (2 credits)

592.  Int Neuro.  Advisory pre-requisite: Enrollment in a Masters' or Ph.D. program. Advanced undergraduates may register only with the permission of the instructor.  (2 to 4 credits)

599.  Grad Ind Research.  Advisory pre-requisite: Graduate Standing  (1 to 8 credits)

600.  Pathophysiology.  Advisory pre-requisite: PHYSIOL 502 or equivalent  (3 credits)

602.  Meth Res Physiology.  Advisory pre-requisite: Physiol. 501, 540, and permission of instructor.  (2 to 6 credits)

603.  Meth Res Physiology.  Advisory pre-requisite: PHYS 602  (2 to 6 credits)

604.  Physiol of Aging.  Advisory pre-requisite: Physiol. 500 or 502, Biol. 420 or equivalent.  (3 credits)

605.  MS Seminar Physiol.  (1 credits)

606.  Current Topics.  Advisory pre-requisite: Graduate standing.  (1 credits)

608.  Hypertension.  Advisory pre-requisite: PER.INSTR.  (2 credits)

610.  Patho & Trans Phys.  Advisory pre-requisite: PHYSIOL 502 or equivalent  (4 credits)

615.  Tech Phys Instructn.  Advisory pre-requisite: PHYSIOL 501  (2 credits)

616.  Tech Phys Instructn.  Advisory pre-requisite: PHYSIOL 501 or permission of instructor  (2 credits)

619.  Homo&Systems Physio.  Advisory pre-requisite: CALC,INTR CS  (3 credits)

620.  Ion Channels.  (2 credits)

626.  Adv Endocrine Phys.  Advisory pre-requisite: System Physiology, Cellular Physiology, Biolchemistry  (3 credits)

627.  Hormonal Reg Metab.  Advisory pre-requisite: PHYSIOL 501 or equivalent; BIOLCHEM or equivalent  (2 credits)

650.  Gastrointestinal.  Advisory pre-requisite: Physiol. 500 or permission of instructor.  (2 credits)

682/CMBIOL 682/CDB 682/MCDB 683/HUMGEN 682/PATH 682/NEUROSCI 682.  Org Complex Tiss.  Advisory pre-requisite: Graduate Cell biology recommended, but not required. Graduate standing.  (2 credits)

684/PATH 684/HUMGEN 684/CDB 684/CMBIOL 684/NEUROSCI 684/BIOLOGY 686.  Org Complex Tiss.  Advisory pre-requisite: Graduate Cell biology recommended, but not required. Graduate standing.  (2 credits)

685/PATH 685/NEUROSCI 685/CDB 685/CMBIOL 685/BIOLOGY 687/HUMGEN 685.  Org Complex Tiss.  Advisory pre-requisite: Graduate Cell biology recommended, but not required. Graduate standing.  (1 credits)

691/NEUROSCI 691.  Cel Neurophysiology.  Advisory pre-requisite: PER.INSTR.  (2 credits)

692/NEUROSCI 692.  Sys&Integ Neurophys.  Advisory pre-requisite: Instructor permission.  (2 credits)

693/NEUROSCI 693/ANATOMY 693.  Cell&Integ Neurophys.  Advisory pre-requisite: Instructor permission.  (4 credits)

699.  Direct Reading-Phys.  (1 to 4 credits)

700.  Physiol MS Capstone.  (2 to 3 credits)

702.  Physio MS Res Proj.  (3 to 8 credits)

703.  Physio MS Res Caps.  Required pre-requisite: PHYSIOL 702  (3 credits)

803.  Mech-Vision.  Advisory pre-requisite: Graduate standing and permission of instructor.  (2 to 3 credits)

806.  Cardiovasc Regulatn.  Advisory pre-requisite: Physiol. 501 or permission of instructor.  (2 credits)

807.  Skeletal Muscle Sem.  Advisory pre-requisite: PHYSIOL 501 or 502 and permission of instructor  (1 credits)

812.  Renal Physiology.  Advisory pre-requisite: Physiol. 501 or permission of instructor.  (2 credits)

822.  Animl Modls-Bio Res.  Advisory pre-requisite: PHYS 503/P.I  (2 credits)

824.  Vertebrate Temp Reg.  Advisory pre-requisite: PER. INSTR.  (2 credits)

990.  Diss-Precand.  Advisory pre-requisite: Election for dissertation work by doctoral student not yet admitted as a Candidate.  (1 to 8 credits)

995.  Diss-Cand.  Required pre-requisite: Candidate  (4 or 8 credits)

PIBS offers you the flexibility and convenience of applying to any of our 14 participating programs through one application. We welcome applications each year from September through December 1.

Although PIBS is a highly selective program, every application is carefully reviewed and evaluated. We work diligently to put together a motivated, diverse, and academically strong class of incoming students every year.

Strong candidates will possess:

  • Extensive research experience in a laboratory setting, including published abstracts or papers
  • Strong letters of recommendation from lab mentor
  • Motivation to pursue research in a resource-rich, interdisciplinary environment

In addition, we seek candidates who have:

  • An exceptional academic record
  • Strong GRE scores

International / non-U.S. citizen applicants must:

  • Select two Ph.D. program/department choices in rank order (please note restrictions above on programs not accepting international applications). On the 'Program Selection' page of the application, click on 'Program in Biomedical Sciences (PIBS)' and select your primary program. You will have an opportunity to select your second program choice on the 'Program-Specific Information' page. These choices are not binding but will be used to determine which programs review your application.
  • Provide a Statement of Purpose that describes your research background, your career goals, and how Michigan's graduate program will help you meet your career and educational objectives. A detailed description of your research experience is strongly recommended. Please limit your Statement of Purpose to two pages.
  • Submit a Personal Statement that describes how your background and life experiences, including cultural, geographical, financial, educational or other opportunities or challenges, motivated your decision to pursue a graduate degree at the University of Michigan. Describe any major obstacles that you had to overcome to achieve your goals. Please limit your Personal Statement to 500 words.
  • Solicit three letters of recommendation from research mentors or professors who can evaluate your academic and scientific potential. These letters must be sent electronically. As you complete the Rackham Graduate School application, you will have the opportunity to send electronic invitations to professors/mentors to submit letters of recommendation. It is highly recommended that you use the online recommender system. If your recommenders are unable to use this system, you should contact PIBS (pibs@umich.edu(link sends e-mail)) immediately for further instructions.
  • Provide GRE scores. Subject GRE scores are not required. [Institution Code 1839. Department code is not needed.]
  • Upload an electronic transcript (can be unofficial scanned version) directly into the online application by the December 1 deadline. You only need to upload transcripts from post-secondary institutions that will result in a degree. Then, as soon as possible, submit an official transcript for any degrees earned or in progress to Rackham Admissions (not to PIBS). Please refer to Rackham’s instructions on uploading and mailing transcripts(link is external).

NOTE: PIBS does not accept hard copies of your materials. All materials must be submitted electronically.

APPLICATION FEES

$90 per application.

The University of Michigan - Ann Arbor offers a comprehensive range of financing options for students enrolled in the Molecular and Integrative Physiology program. Prospective and current students can access various financial aid opportunities to support their academic pursuits. Federal financial aid programs, including the Free Application for Federal Student Aid (FAFSA), are available to qualifying students, providing grants, loans, and work-study options to reduce the financial burden of higher education. The university also offers institutional scholarships and fellowships specifically tailored to students in health sciences and related fields, which are awarded based on academic merit, financial need, or specific criteria related to research interests.

Additionally, students may explore external funding sources such as private scholarships, research grants, and stipends from academic departments or affiliated research centers. Graduate students, including those pursuing advanced degrees in Molecular and Integrative Physiology, often have opportunities for assistantships, such as teaching assistantships or research assistantships, which provide a stipend and tuition remission in exchange for teaching or research responsibilities. The university’s Office of Financial Aid and Student Scholarships provides detailed guidance and personalized assistance to help students navigate their financing options, complete application processes, and access resources for loan counseling and financial planning.

Financial planning resources, including workshops and one-on-one consultations, are available throughout the academic year to ensure students can make informed decisions about funding their education. The university also emphasizes the importance of early application for financial aid programs and advises students to meet specified deadlines to maximize their eligibility for available funding. Overall, the University of Michigan - Ann Arbor is committed to ensuring that financial barriers do not impede qualified students from pursuing a degree in Molecular and Integrative Physiology by offering diverse and accessible financing options.

The Molecular and Integrative Physiology program at the University of Michigan in Ann Arbor offers students a comprehensive understanding of the biological mechanisms that underpin human health and disease. This program is designed to provide a strong foundation in the principles of physiology, blending molecular techniques with systems-level understanding to prepare students for careers in biomedical research, healthcare, or further academic study. Students enrolled in the program engage in coursework that covers a broad range of topics, including cellular physiology, neurophysiology, cardiovascular physiology, and muscle physiology. The curriculum emphasizes both theoretical knowledge and practical laboratory skills, enabling students to apply scientific methods to investigate physiological processes.

Research opportunities are a vital aspect of the program, with students working alongside faculty members who are leaders in their fields. These research projects often involve cutting-edge techniques such as molecular biology, electrophysiology, imaging, and data analysis, providing students with valuable experience translating laboratory findings into biomedical insights. The program also encourages interdisciplinary approaches, integrating aspects of molecular biology, biochemistry, and systems biology to understand complex physiological phenomena.

Graduates of the Molecular and Integrative Physiology program are well-equipped for diverse career paths, including graduate or medical school, research positions in academia or industry, and clinical roles. The program benefits from the university’s extensive resources, including state-of-the-art laboratories, collaborative research centers, and a vibrant academic community dedicated to advancing knowledge in life sciences. Students develop critical thinking, technical competencies, and a deep understanding of physiological principles, positioning them to contribute meaningfully to advancements in health sciences and personalized medicine. The program's integrative approach ensures that students not only grasp individual biological components but also their interactions within the entire organism, echoing the university's commitment to holistic scientific education and innovation.

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