| Level: | PhD |
| Tuition: | Full coverage |
| Deadline: | Jan 22, 2025 |
| Duration max: | 99 months |
Description
We are all familiar with the rapid and dramatic weight loss that accompanies the decline of a seriously ill loved-one or friend. This “wasting” is not a disease in itself, but a consequence of disease. By preventing it, there is little argument that patient well-being would be improved.
Virtually all body proteins are continually made and destroyed and this is maintained is through the process of protein homeostasis, or proteostasis. Normally, proteins are synthesised and degraded in an equilibrium ensuring constant protein levels. Changes in abundance are mediated by adjusting the rates of synthesis and/or degradation, that is, the rate of protein “turnover”. But in wasting, the balance is lost, and we degrade more proteins than we make.
You will join a strong team of multidisciplinary researchers investigating the fundamental cellular process of proteostasis and investigate the changes in protein expression, turnover and activity that underlie the development and progression of the muscle wasting synonymous with chronic illness, in this case the cachexia induced by cancer.
Within cells, the two main protein degradation pathways with broad selectivity are lysosome-mediated autophagy and the ubiquitin proteasome system. In animal models of skeletal muscle wasting, there are increased levels of ubiquitinated proteins, suggesting an increased formation of ubiquitinated proteins that are then targeted to the proteasome for degradation. Expression of several enzymes in the ubiquitin conjugation pathway are induced in wasted muscle but their genetic inactivation only partially protects from muscle wasting, suggesting that other mechanisms may be involved. Opposing the enzymes involved in ubiquitin conjugation are the deubiquitinating enzymes. The potential role of these in muscle wasting is largely unexplored.
Available for
- Afghanistan
- Albania
- Antarctica
- Algeria
- American Samoa
- Andorra
- Angola
- Antigua and Barbuda
- Azerbaijan
- Argentina
- Australia
- Austria
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- Bahrain
- Bangladesh
- Armenia
- Barbados
- Belgium
- Bermuda
- Bhutan
- Bolivia
- Bosnia and Herzegovina
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- Bouvet Island
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- Solomon Islands
- Virgin Islands, British
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- Taiwan
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- Mayotte
- Congo
- Congo
- Cook Islands
- Costa Rica
- Croatia
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- Cyprus
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- Benin
- Denmark
- Dominica
- Dominican Republic
- Ecuador
- El Salvador
- Equatorial Guinea
- Ethiopia
- Eritrea
- Estonia
- Faroe Islands
- Falkland Islands (Malvinas)
- South Georgia and the South Sandwich Islands
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- Gibraltar
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- Guam
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- Guyana
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- Iceland
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- Indonesia
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- Italy
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- South Korea
- Kuwait
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- Laos
- Lebanon
- Lesotho
- Latvia
- Liberia
- Libya
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- Luxembourg
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- Malaysia
- Maldives
- Mali
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- Martinique
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- Mozambique
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- Aruba
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- Bonaire, Sint-Estatius and Saba
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- Guinea-Bissau
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- Puerto Rico
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- Reunion
- Romania
- Russian Federation
- Rwanda
- Saint Barthelemy
- Saint Helena
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- Anguilla
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- San Marino
- Sao Tome and Principe
- Saudi Arabia
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- Seychelles
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- Singapore
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- Vietnam
- Slovenia
- Somalia
- South Africa
- Zimbabwe
- Spain
- Southern Sudan
- Sudan
- Western Sahara
- Suriname
- Svalbard and Jan Mayen Islands
- Swaziland
- Sweden
- Switzerland
- Syrian Arab Republic
- Tajikistan
- Thailand
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- Tokelau
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- Tunisia
- Turkey
- Turkmenistan
- Turks and Caicos Islands
- Tuvalu
- Uganda
- Ukraine
- North Macedonia
- Egypt
- United Kingdom
- Guernsey
- Jersey
- Isle of Man
- Tanzania, United Republic of
- United States
- Virgin Islands, U.S.
- Burkina Faso
- Uruguay
- Uzbekistan
- Venezuela
- Wallis and Futuna
- Samoa
- Yemen
- Zambia
- South Ossetia
- Kosovo
- Vanuatu
- Aland Islands
- French Southern and Antarctic Lands
Disciplines
- Life Sciences, Medicine & Health
Benefits
CASE studentships are funded by the Biotechnology and Biological Sciences Research Council (BBSRC) for 4 years. Funding will cover tuition fees at the UK rate only, a Research Training and Support Grant (RTSG) and stipend. We aim to support the most outstanding applicants from outside the UK and are able to offer a limited number of bursaries that will enable full studentships to be awarded to international applicants. These full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme.
Requirements
Open to students worldwide
Targets
Currency
EUR
GBP
KZT
INR
RUB