Biochemistry and Molecular Biophysics

The Biochemistry and Molecular Biophysics program at the California Institute of Technology offers students a comprehensive education at the forefront of scientific research and innovation in the chemical and physical principles underlying biological systems. This interdisciplinary program is designed to prepare students for careers in academia, industry, or government by providing a rigorous foundation in chemistry, physics, biology, and mathematics, with an emphasis on the molecular mechanisms that drive life processes. Students engage in advanced coursework covering topics such as molecular structure and dynamics, enzymology, genetics, and biophysical methods, complemented by hands-on laboratory experiments and cutting-edge research projects. The program encourages critical thinking and problem-solving skills, enabling students to analyze complex biological phenomena through quantitative and experimental approaches. Collaborative opportunities with faculty members involved in pioneering research across areas like structural biology, bioinformatics, and systems biology foster an environment of innovation and discovery. Graduates of the program are well-equipped to contribute to scientific advancements in drug development, biotechnology, medical research, and environmental science. The program also emphasizes the importance of effective communication and teamwork in scientific endeavors, preparing students to be leaders in their fields. With access to state-of-the-art facilities and individualized mentoring, students are supported throughout their academic journey to achieve their professional goals. Overall, the Biochemistry and Molecular Biophysics program at Caltech provides an exceptional education that combines theoretical knowledge with practical skills, empowering students to make meaningful contributions to the understanding and application of molecular life sciences.

Selecting an Advisor and Laboratory Rotations - First Year

The Option Graduate Study Committee will counsel and oversee the student's progress upon admission to the graduate program. In the first year of graduate study, the course requirement consists of a sequence of three core courses covering the biochemistry and biophysics of macromolecules and molecular assemblies (BMB 170 abc). These courses will expose the student to contemporary issues in biochemistry and molecular biophysics, and to the tools and methods that are essential for research in this area. Research advisors are normally selected at the end of the first year. In consultation with their advisor, students are expected to take three additional advanced courses of 9 or more units in the first and second years that are appropriate for their particular research interests.

In consultation with the Option Graduate Study Committee and individual professors, students will choose three laboratories in which to do short research projects during their first year of residence. These laboratory rotations are designed to provide the student with an introduction to different areas of biochemistry. It is possible to waive some or all of the rotations by petitioning the Option Graduate Study Committee.

Candidacy Examination - Second Year

By the end of the sixth term of residency (spring term of the second year), the student will take an oral examination to assess mastery of the field of biochemistry and to evaluate research progress. As part of this examination, each student will submit a written research report summarizing the progress in their research, and an original research proposition in a field outside the student's chosen field of research. A candidacy examination committee will be assembled by the student in consultation with his/her thesis advisor (the student is responsible for finding a date, time and location for the exam). The committee should consist of the student's thesis advisor and three or four BMB faculty members (faculty outside of the BMB option may also be members of the committee), and is chaired by a faculty member other than the student's advisor. When the student advances to candidacy upon successful completion of the exam, the exam committee will become the thesis advisory committee and will meet with the student once a year to evaluate research progress. This committee will also serve as the PhD thesis advisory committee.

Annual Thesis Advisory Committee Meetings - Third Year and up to Ph.D. defense

Students are required to meet annually with their Thesis Advisory Committee to evaluate research progress and to get feedback on their experiments and future plans.

Ph.D. Thesis Defense

All Ph.D. candidates must present their work in a thesis seminar.

Master's Degree in Biochemistry

Students are not normally admitted to work toward the M.S. degree. In special circumstances, the M.S. degree may be awarded, provided Institute requirements are met. In general, the degree is not conferred until the end of the second year of residence.

Seminars

Students have the opportunity to attend a wide range of seminars, from weekly informal group seminars to named lectureships. BMB graduate students actively participate in the regularly scheduled BMB seminars by attending BMB202. Graduate students actively participate in the regularly scheduled seminars. These seminars are organized and operated by graduate students who select and invite the speakers as well as arrange appointment schedules. There are also seminar series in physics, biology, and chemistry that may interest BMB graduate students.

Teaching

All students are expected to serve as a graduate teaching assistant for one quarter a year through their fourth year of residence. Assignments may consist of leading a recitation section in an undergraduate course or acting as an assistant in an undergraduate laboratory course. Advanced graduate students often help with graduate level courses. Class sizes at Caltech are small thus enhancing the teaching experience.

Requirements

• Master's degree in the related area
• Statement of Purpose
• Include payment of the application fee or submit a fee waiver request. 
• Three letters of recommendation from individuals familiar with your academic and/or work performance are required for all applicants. 
• Transcripts from all colleges or universities attended are required. Transcripts may be sent directly from the Registrar of the institution you attended or transcripts issued directly to the applicant, and so marked, are acceptable, and can be submitted online following the electronic submission process. If you attended Caltech as an undergraduate, you must request an official transcript from the Office of the Registrar. We cannot obtain one on your behalf. 
• Attach a CV or resume
• TOEFL

The Biochemistry and Molecular Biophysics undergraduate program at the California Institute of Technology primarily offers financial support through various means. Most students pursuing this program are eligible for Caltech’s need-based financial aid, which aims to make education accessible regardless of economic background. The institute commits to meeting 100% of demonstrated financial need for admitted students through a combination of grants and scholarships that do not require repayment, significantly reducing the financial burden on students. Caltech's financial aid office provides detailed guidance and support to applicants and current students, helping them navigate the process of applying for aid and understanding the available resources.

In addition to need-based aid, students may have access to scholarships and awards based on academic merit, contributions to the community, or specific departmental honors. These awards are competitive and are intended to recognize exceptional achievement and motivation within the field of biochemistry and biophysics. Some students may also secure external scholarships from private organizations, foundations, or government-sponsored programs, which can supplement their funding and reduce reliance on institutional aid.

Work-study opportunities are typically available on campus, allowing students to gain valuable research or administrative experience while earning additional income to support their studies. Caltech encourages students to participate in research projects and offers stipends or other financial incentives for students involved in laboratory work or scientific research, particularly in the biochemistry and molecular biophysics departments.

Graduate students in related programs may also have access to teaching assistantships, research assistantships, or fellowships, which provide substantial stipends and tuition waivers. While undergraduate funding mechanisms are primarily need-based and merit-based aid, the institution’s overall commitment to affordability and financial support ensures that students can focus on their academic and research pursuits without undue financial stress.

The institute’s approach to financing studies emphasizes transparency and comprehensive support, aiming to ensure that absence of financial resources does not hinder talented students from pursuing their educational goals in biochemistry and molecular biophysics.

California Institute of Technology (Caltech) offers a rigorous and comprehensive undergraduate program in Biochemistry and Molecular Biophysics. This interdisciplinary major combines principles from chemistry, biology, physics, and mathematics to provide students with a deep understanding of the molecular mechanisms underlying biological processes. The curriculum is designed to equip students with both theoretical knowledge and practical skills, including laboratory techniques, data analysis, and experimental design. Students in this program have access to state-of-the-art research facilities and are encouraged to participate in cutting-edge research projects alongside leading faculty members. The program emphasizes a strong foundation in chemistry and biology, complemented by coursework in physical principles applicable to biomolecular systems, computational methods, and biophysical techniques. Graduates are prepared for careers in research, healthcare, biotechnology, or further academic study in graduate or professional schools. The program's structure allows for flexibility, enabling students to tailor their coursework to specific interests such as structural biology, enzymology, or molecular genetics. Caltech’s unique emphasis on research and discovery fosters an environment where students can develop innovative approaches to scientific problems. Additionally, the program collaborates with various research institutes and industry partners, providing valuable internship and networking opportunities. The faculty comprises leading scientists and researchers who are committed to mentorship and advancing knowledge in biochemistry and molecular biophysics. Overall, this program aims to cultivate scientifically curious, technically skilled, and innovative graduates capable of making meaningful contributions in science and technology fields.